Shedding of NG2 by MMP-13 attenuates anoikis.

@article{Joo2014SheddingON,
  title={Shedding of NG2 by MMP-13 attenuates anoikis.},
  author={Nam Eok Joo and Di Miao and Mercedes Berm{\'u}dez and William B Stallcup and Yvonne L Kapila},
  journal={DNA and cell biology},
  year={2014},
  volume={33 12},
  pages={854-62}
}
Disruption of cell-matrix interactions can lead to anoikis-apoptosis due to loss of matrix contacts. We previously showed that Nerve/glial antigen 2 (NG2) is a novel anoikis receptor. Specifically, overexpression of NG2 leads to anoikis propagation, whereas its suppression leads to anoikis attenuation. Interestingly, NG2 expression decreases in late anoikis, suggesting that NG2 reduction is also critical to this process. Thus, we hypothesized that NG2 undergoes cleavage to curtail anoikis… CONTINUE READING

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Matrix metalloproteinases and myeloperoxidase in gingival crevicular fluid provide sitespecific diagnostic value for chronic periodontitis

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