Shedding of Ebola Virus Surface Glycoprotein Is a Mechanism of Self-regulation of Cellular Cytotoxicity and Has a Direct Effect on Virus Infectivity.

@article{Dolnik2015SheddingOE,
  title={Shedding of Ebola Virus Surface Glycoprotein Is a Mechanism of Self-regulation of Cellular Cytotoxicity and Has a Direct Effect on Virus Infectivity.},
  author={Olga Dolnik and Valentina A. Volchkova and Beatriz Escudero-P{\'e}rez and Philip Lawrence and Hans Dieter Klenk and Viktor E. Volchkov},
  journal={The Journal of infectious diseases},
  year={2015},
  volume={212 Suppl 2},
  pages={S322-8}
}
The surface glycoprotein (GP) is responsible for Ebola virus (EBOV) attachment and membrane fusion during virus entry. Surface expression of highly glycosylated GP causes marked cytotoxicity via masking of a wide range of cellular surface molecules, including integrins. Considerable amounts of surface GP are shed from virus-infected cells in a soluble truncated form by tumor necrosis factor α-converting enzyme. In this study, the role of GP shedding was investigated using a reverse genetics… CONTINUE READING
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