Shedding of APP limits its synaptogenic activity and cell adhesion properties

  title={Shedding of APP limits its synaptogenic activity and cell adhesion properties},
  author={Ronny Stahl and Sandra Schilling and Peter Soba and Carsten Rupp and Tobias Hartmann and Katja Wagner and Gunter Merdes and Simone Eggert and Stefan Kins},
  booktitle={Front. Cell. Neurosci.},
The amyloid precursor protein (APP) plays a central role in Alzheimer's disease (AD) and has essential synapse promoting functions. Synaptogenic activity as well as cell adhesion properties of APP presumably depend on trans-cellular dimerization via its extracellular domain. Since neuronal APP is extensively processed by secretases, it raises the question if APP shedding affects its cell adhesion and synaptogenic properties. We show that inhibition of APP shedding using cleavage deficient forms… CONTINUE READING
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