Shedding new light on female fertility: The role of vitamin D

  title={Shedding new light on female fertility: The role of vitamin D},
  author={Giovanna Muscogiuri and Barbara Altieri and Cristina de Angelis and Stefano Palomba and Rosario Pivonello and Annamaria Colao and Francesco Orio},
  journal={Reviews in Endocrine and Metabolic Disorders},
In the last decades several studies suggested that vitamin D is involved in the modulation of the reproductive process in women due to the expression of VDR and 1α-hydroxylase in reproductive tissues such as ovary, uterus, placenta, pituitary and hypothalamus. Vitamin D has also a role in the regulation of sex hormone steroidogenesis. Increasing evidence suggests that vitamin D might have a regulatory role in polycystic ovary syndrome (PCOS)-associated symptoms, including ovulatory dysfunction… 

The role of vitamin D in male fertility: A focus on the testis

Clinical and experimental studies in humans and animals addressing the relationship between vitamin D and testis function and vitamin D was shown to be positively associated to sperm motility, and to exert direct actions on spermatozoa, including non-genomic driven modulation of intracellular calcium homeostasis.

Vitamin D and Male Fertility: An Updated Review

An updated systematic revision of the current available literature on the role of vitamin D in the regulation of testis hormone production, seminal parameters and male fertility is provided, discussing the experimental and clinical evidence.

The Relationship Between Female Reproductive Functions and Vitamin D

To be able to recommend measuring vitamin D as a routine screening test and to better understand the effects of vitamin D and its supplementation on female reproductive functions, larger randomized controlled prospective studies are needed.

Vitamin D3 action within the ovary - an updated review.

The objective of this review is to summarize the knowledge about the contribution of vitamin D3 to physiological and pathological processes within the ovary.

Effects of Vitamin D on Fertility, Pregnancy and Polycystic Ovary Syndrome—A Review

Vitamin D supplementation and optimal vitamin D levels decrease both maternal and fetal risk for complications and adverse events and may ameliorate or even prevent pregnancy-related reversible bone loss in mothers.

Is there a relationship between Vitamin D and Endometriosis? An overview of literature.

Although promising, the data analyzed are not sufficient to evidence a cause-effect relationship between VD status and endometriosis, therefore further studies are needed in order to better clarify the association between vitamin D and endometricriosis.

Relationship between endometriosis and vitamin D status - a review

The authors summarise the current state of knowledge of the impact of vitamin D on the function of the female genital tract, with special focus on the incidence and development of endometriosis.

Vitamin D3 Regulates Follicular Development and Intrafollicular Vitamin D Biosynthesis and Signaling in the Primate Ovary

A role for VD3 in regulating follicular development in a stage-dependent manner, as well as the intrafollicular vitamin D biosynthesis and signaling, directly in the ovary is supported.

Vitamin D improves levels of hormonal, oxidative stress and inflammatory parameters in polycystic ovary syndrome: a meta-analysis study.

It is demonstrated that vitamin D supplementation in patients with PCOS resulted in an improvement in the levels of TT, hs-CRP, TAC, and MDA, but did not affect FT, DHEA-S, SHBG, FAI, NO, and GSH levels.

The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data

It is still not clear whether vitamin D supplementation improves fertility or decreases the risk of adverse pregnancy outcomes such as low birth weight, pre-eclampsia and neonatal mortality, or reduces wheeze/asthma in the infants.



Vitamin D and fertility: a systematic review.

Evidence that vitamin D is involved in female reproduction including IVF outcome (clinical pregnancy rates) and polycystic ovary syndrome (PCOS) is presented and vitamin D supplementation might improve menstrual frequency and metabolic disturbances in women.

The Pleiotropic Effects of Vitamin D in Gynaecological and Obstetric Diseases: An Overview on a Hot Topic

The relationship between vitamin D and gynaecological/obstetric diseases must be replicated in future studies which could clarify the molecular machineries behind their development.

Role of vitamin D in female reproduction.

Focus on vitamin D and the adrenal gland.

Although many studies support a beneficial role of vitamin D in adrenal disease, randomized controlled trials and mechanistic studies are required to provide more insight into the efficacy and safety of vitaminD as a therapeutic tool.

Vitamin D in the aetiology and management of polycystic ovary syndrome

There may be a place for vitamin D supplementation in the management of this syndrome, but current evidence is limited and additional randomized controlled trials are required to confirm the potential benefits of vitamin D supplements in this population.

Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads.

It is indicated that vitamin D is essential for full gonadal function in both sexes and direct regulation of the expression of the aromatase gene should not be neglected.

Effect of vitamin D3 treatment on glucose metabolism and menstrual frequency in polycystic ovary syndrome women: A pilot study

It is suggested that vitamin D treatment might improve glucose metabolism and menstrual frequency in PCOS women and randomized controlled trails are warranted to confirm the findings.

Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells.

The data suggest that vit D3 alters AMH signaling and steroidogenesis in human cumulus GCs, possibly reflecting a state of GC luteinization potentiation.

Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system.

The IL-1beta-mediated induction of 1alpha-OHase gene and the hormonal modulation of osteopontin support a role for the hormone in the immunological mechanisms underlying uterine function.

Serum Vitamin D Levels and Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis

It was found that lower serum vitamin D levels were related to metabolic and hormonal disorders in women with PCOS, and PCOS patients with VDD were more likely to have dysglycemia.