Shedding light on the Na+/Ca2+ exchanger.

  title={Shedding light on the Na+/Ca2+ exchanger.},
  author={Michela Ottolia and Scott A. John and Yi Xie and Xiaoyan Ren and Kenneth D. Philipson},
  journal={Annals of the New York Academy of Sciences},
The Na+/Ca2+ exchanger (NCX) regulates cardiac contractility by adjusting the amount of Ca2+ inside myocytes. NCX accomplishes this by using the electrochemical gradient of Na+: during each cycle three Na+ ions enter the cell and one Ca2+ ion is extruded against its gradient. In addition to being transported, cytoplasmic Na+ and Ca2+ ions also regulate exchanger activity. The physiological relevance and molecular processes underlying ionic regulation remain unclear. Also unresolved are the… CONTINUE READING


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