Shed GP of Ebola Virus Triggers Immune Activation and Increased Vascular Permeability

@inproceedings{EscuderoPrez2014ShedGO,
  title={Shed GP of Ebola Virus Triggers Immune Activation and Increased Vascular Permeability},
  author={Beatriz Escudero-P{\'e}rez and Valentina A. Volchkova and Olga Dolnik and Philip Lawrence and Viktor E. Volchkov},
  booktitle={PLoS pathogens},
  year={2014}
}
During Ebola virus (EBOV) infection a significant amount of surface glycoprotein GP is shed from infected cells in a soluble form due to cleavage by cellular metalloprotease TACE. Shed GP and non-structural secreted glycoprotein sGP, both expressed from the same GP gene, have been detected in the blood of human patients and experimentally infected animals. In this study we demonstrate that shed GP could play a particular role during EBOV infection. In effect it binds and activates non-infected… CONTINUE READING

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