Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization.

@article{Thienen2006ShearSS,
  title={Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization.},
  author={Johannes V. van Thienen and Joost O. Fledderus and Rob J. Dekker and Jakub Rohlena and Gerben A van Ijzendoorn and Neeltje A Kootstra and H. Pannekoek and Anton J. G. Horrevoets},
  journal={Cardiovascular research},
  year={2006},
  volume={72 2},
  pages={231-40}
}
OBJECTIVE The transcription factor KLF2 is considered an important mediator of the anti-inflammatory and anti-thrombotic properties of the endothelium. KLF2 is absent from low-shear, atherosclerosis-prone sites of the vascular tree but is induced by HMG-CoA reductase inhibitors (statins) in vitro. We studied KLF2-dependent induction of important determinants of the atheroprotective status of the endothelium to determine whether pharmacological intervention, e.g. by statins, can potentially… CONTINUE READING

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