Shear stress regulates aquaporin-5 and airway epithelial barrier function.

  title={Shear stress regulates aquaporin-5 and airway epithelial barrier function.},
  author={Venkataramana K Sidhaye and Kelly S. Schweitzer and Michael J. Caterina and Larissa A. Shimoda and L. S. King},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 9},
As the interface with the outside world, the airway epithelial barrier is critical to lung defense. Because of respiratory efforts, the airways are exposed to shear stress; however, little is known regarding the effects of shear on epithelial function. We report that low-level shear stress enhances epithelial barrier function, an effect that requires serial activation of the transient receptor potential vanilloid (TRPV) 4 and L-type voltage-gated calcium channel (VGCC) and an increase in… CONTINUE READING
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