Shear stress promotes nitric oxide production in endothelial cells by sub-cellular delocalization of eNOS: A basis for shear stress mediated angiogenesis.

@article{Kolluru2010ShearSP,
  title={Shear stress promotes nitric oxide production in endothelial cells by sub-cellular delocalization of eNOS: A basis for shear stress mediated angiogenesis.},
  author={Gopi Krishna Kolluru and Swaraj Sinha and Syamantak Majumder and Ajit Muley and Jamila H Siamwala and Ravi Gupta and Suvro Chatterjee},
  journal={Nitric oxide : biology and chemistry},
  year={2010},
  volume={22 4},
  pages={
          304-15
        }
}
This study aims to investigate the role of shear stress in cellular remodeling and angiogenesis with relation to nitric oxide (NO). We observed a 2-fold increase in endothelial cell (EC) migration in relation to actin re-arrangements under 15 dyne/cm(2) shear stress. Blocking NO production inhibited the migration and ring formation of ECs by 6-fold and 5-fold, respectively under shear stress. eNOS-siRNA knockdown technique also ascertained a 3-fold reduction in shear stress mediated ring… CONTINUE READING
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