Shear stress paradigm for perinatal fractal arterial network remodeling in lambs with pulmonary hypertension and increased pulmonary blood flow.

@article{Ghorishi2007ShearSP,
  title={Shear stress paradigm for perinatal fractal arterial network remodeling in lambs with pulmonary hypertension and increased pulmonary blood flow.},
  author={Zahra Ghorishi and Jay M. Milstein and Francis R. Poulain and Anita Moon-Grady and Theresa Ann Tacy and Stephen H. Bennett and Jeffery R Fineman and Marlowe W. Eldridge},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={292 6},
  pages={H3006-18}
}
Congenital heart disease with increased blood flow commonly leads to the development of increased pulmonary vascular reactivity and pulmonary arterial hypertension by mechanisms that remain unclear. We hypothesized a shear stress paradigm of hemodynamic reactivity and network remodeling via the persistence and/or exacerbation of a fetal diameter bifurcation phenotype [parent diameter d(0) and daughters d(1) >or= d(2) with alpha < 2 in (d(1)/d(0))(alpha) + (d(2)/d(0))(alpha) and area ratio beta… CONTINUE READING

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