Shear stress-induced binding of von Willebrand factor to platelets.

  title={Shear stress-induced binding of von Willebrand factor to platelets.},
  author={Konstantinos Konstantopoulos and Toby W S Chow and Nancy A. Turner and J. David Hellums and Joel L. Moake},
  volume={34 1},
Shear stress-induced platelet aggregation requires von Willebrand factor (vWF), platelet glycoprotein (GP) Ib, GPIIb-IIIa, Ca2+, and adenosine diphosphate (ADP). Recent reports using vWF labeled with either 125I or fluorescein isothiocyanate (FITC) have demonstrated that in shear-fields, vWF binds to both GPIb and GPIIb-IIIa. The sequence of the vWF finding to the two platelet receptors has not been precisely determined in these reports. In this study, a flow cytometry technique using a primary… CONTINUE READING


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