Shear stress increases the amount of S-nitrosylated molecules in endothelial cells: important role for signal transduction.

@article{Hoffmann2003ShearSI,
  title={Shear stress increases the amount of S-nitrosylated molecules in endothelial cells: important role for signal transduction.},
  author={J{\"o}rg Hoffmann and Stefanie Dimmeler and Judith Haendeler},
  journal={FEBS letters},
  year={2003},
  volume={551 1-3},
  pages={153-8}
}
Laminar flow (shear stress) is an important stimulus for nitric oxide (NO) synthesis in endothelial cells. NO can react with free SH-groups of different proteins leading to S-nitrosylation. Since S-nitrosylation of proteins is an important regulator of protein functions, we investigated the effect of endogenously synthesized NO. Exposure to shear stress significantly increased the overall S-nitrosylation of proteins in endothelial cells. Interestingly, shear stress increased S-nitrosylation of… CONTINUE READING

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