Shear stress increases cytotoxicity and reduces transfection efficiency of liposomal gene delivery to CHO-S cells.

Abstract

Animal cells in suspension experience shear stress in different situations such as in vivo due to hemodynamics, or in vitro due to agitation in large-scale bioreactors. Shear stress is known to affect cell physiology, including binding and uptake of extracellular cargo. In adherent cells the effects of exposure to shear stress on particle binding kinetics… (More)

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