Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique.

@article{Cheng2005ShearSA,
  title={Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique.},
  author={C. Cheng and R. van Haperen and M. D. de Waard and L. V. van Damme and D. Tempel and Laurens Hanemaaijer and G. V. van Cappellen and Joop Bos and C. Slager and D. Duncker and A. V. D. van der Steen and R. de Crom and R. Krams},
  journal={Blood},
  year={2005},
  volume={106 12},
  pages={
          3691-8
        }
}
The focal location of atherosclerosis in the vascular tree is correlated with local variations in shear stress. We developed a method to induce defined variations in shear stress in a straight vessel segment of a mouse. To this end, a cylinder with a tapered lumen was placed around the carotid artery, inducing a high shear stress field. Concomitantly, regions of low shear stress and oscillatory shear stress were created upstream and down-stream of the device, respectively. This device was used… Expand
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