Shear stress activation of nuclear receptor PXR in endothelial detoxification.

  title={Shear stress activation of nuclear receptor PXR in endothelial detoxification.},
  author={Xiaohong Wang and Xi Fang and Jing Zhou and Zhen Chen and Beilei Zhao and Lei Xiao and Ao Liu and Yi-shuan Julie Li and John Y-J Shyy and You-fei Guan and Shu Chien and Nanping Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 32},
Endothelial cells (ECs) are constantly exposed to xenobiotics and endobiotics or their metabolites, which perturb EC function, as well as to shear stress, which plays a crucial role in vascular homeostasis. Pregnane X receptor (PXR) is a nuclear receptor and a key regulator of the detoxification of xeno- and endobiotics. Here we show that laminar shear stress (LSS), the atheroprotective flow, activates PXR in ECs, whereas oscillatory shear stress, the atheroprone flow, suppresses PXR. LSS… CONTINUE READING
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