Shear stress, SIRT1, and vascular homeostasis

@article{Chen2010ShearSS,
  title={Shear stress, SIRT1, and vascular homeostasis},
  author={Zhen Chen and I-Chen Peng and Xiaopei Cui and Yi-shuan Julie Li and Shu Chien and John Y.-J. Shyy},
  journal={Proceedings of the National Academy of Sciences},
  year={2010},
  volume={107},
  pages={10268 - 10273}
}
Shear stress imposed by blood flow is crucial for maintaining vascular homeostasis. We examined the role of shear stress in regulating SIRT1, an NAD+-dependent deacetylase, and its functional relevance in vitro and in vivo. The application of laminar flow increased SIRT1 level and activity, mitochondrial biogenesis, and expression of SIRT1-regulated genes in cultured endothelial cells (ECs). When the effects of different flow patterns were compared in vitro, SIRT1 level was significantly higher… Expand
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