Shear-sensitive microRNA-34a modulates flow-dependent regulation of endothelial inflammation.

@article{Fan2015ShearsensitiveMM,
  title={Shear-sensitive microRNA-34a modulates flow-dependent regulation of endothelial inflammation.},
  author={Wendong Fan and Rong Fang and Xiao-Yuan Wu and Jia Liu and Mingzhe Feng and Gang Dai and Guojun Chen and Guifu Wu},
  journal={Journal of cell science},
  year={2015},
  volume={128 1},
  pages={70-80}
}
Although many studies have described the roles of microRNAs (miRNAs) in the modulation of the endothelial response to shear stress, the mechanisms remain incompletely understood. Here, we demonstrate that miR-34a expression in endothelial cells was downregulated by atheroprotective physiological high shear stress (HSS), whereas it was upregulated by atheroprone oscillatory shear stress (OSS). Blockade of endogenous miR-34a dramatically decreased basal vascular cell adhesion molecule-1 (VCAM-1… CONTINUE READING
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