Shear level influences resistance artery remodeling: wall dimensions, cell density, and eNOS expression.

@article{Tuttle2001ShearLI,
  title={Shear level influences resistance artery remodeling: wall dimensions, cell density, and eNOS expression.},
  author={Jay L. Tuttle and Ryan D. Nachreiner and Amardip S. Bhuller and Kristin Condict and Bret A. Connors and Brian Paul Herring and Michael C. Dalsing and Joseph L. Unthank},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={281 3},
  pages={
          H1380-9
        }
}
The magnitude of shear stimulus has been shown to determine the level of growth factor expression in cell culture. However, little is known regarding what effect shear level has on specific arterial wall remodeling events in vivo. We have hypothesized that the rate of luminal diameter change and specific remodeling events within the arterial wall layers are dependent on shear level. Selective ligations were made to alter the number of microvascular perfusion units of mesenteric arteries within… CONTINUE READING

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