Shear-induced variability in the United States pharmacopeia apparatus 2: Modifications to the existing system

Abstract

The hydrodynamics within the United States Pharmacopeia Apparatus 2 have been shown to be highly non-uniform with a potential to yield substantial variability in dissolution rate measurements. Through the use of readily available engineering tools, several geometric modifications to the device were evaluated in this study. Specifically, we examined the… (More)
DOI: 10.1208/aapsj070483

Topics

8 Figures and Tables

Cite this paper

@article{Baxter2006ShearinducedVI, title={Shear-induced variability in the United States pharmacopeia apparatus 2: Modifications to the existing system}, author={Jennifer L. Baxter and Joseph Kukura and Fernando J. Muzzio}, journal={The AAPS Journal}, year={2006}, volume={7}, pages={E857-E864} }