Shear-induced platelet adhesion and aggregation on subendothelium are increased in diabetic patients.

@article{Knobler1998ShearinducedPA,
  title={Shear-induced platelet adhesion and aggregation on subendothelium are increased in diabetic patients.},
  author={Hilla Knobler and Naphtali Savion and Boris Shenkman and Shlomo Kotev-Emeth and David Ju{\'a}rez Var{\'o}n},
  journal={Thrombosis research},
  year={1998},
  volume={90 4},
  pages={
          181-90
        }
}
Increased platelet aggregation has been suggested to play a role in the accelerated atherosclerosis of diabetics. However the physiological relevance of the aggregation tests has been questioned. The purpose of this study was to determine platelet activation in diabetic patients, using a novel device--the cone and plate(let) analyzer--to measure shear-induced platelet adhesion and aggregation on extracellular matrix (ECM). Whole blood platelet adhesion and aggregation in patients with… CONTINUE READING

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