Shear-induced global thrombosis test of native blood: pivotal role of ADP allows monitoring of P2Y12 antagonist therapy.

@article{Saraf2009ShearinducedGT,
  title={Shear-induced global thrombosis test of native blood: pivotal role of ADP allows monitoring of P2Y12 antagonist therapy.},
  author={Smriti Saraf and David M. Wellsted and Seema Sharma and Diana A. Gorog},
  journal={Thrombosis research},
  year={2009},
  volume={124 4},
  pages={447-51}
}
BACKGROUND It is claimed that in shear-induced platelet function tests, shear-stress is the sole agonist causing platelet activation and resultant thrombosis. However, the fact that red blood cells (RBC) are essential to achieve platelet aggregation in these tests supports recent evidence that ADP makes an important contribution to shear-induced platelet reaction. AIM To establish the role of ADP in shear-induced thrombosis, and investigate whether a shear-induced thrombosis test can assess… CONTINUE READING