Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications

@article{Hsieh2013ShearinducedEM,
  title={Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications},
  author={H. Hsieh and Ching-Ann Liu and B. Huang and Anne HH Tseng and D. Wang},
  journal={Journal of Biomedical Science},
  year={2013},
  volume={21},
  pages={3 - 3}
}
  • H. Hsieh, Ching-Ann Liu, +2 authors D. Wang
  • Published 2013
  • Medicine, Biology
  • Journal of Biomedical Science
  • Hemodynamic shear stress, the blood flow-generated frictional force acting on the vascular endothelial cells, is essential for endothelial homeostasis under normal physiological conditions. Mechanosensors on endothelial cells detect shear stress and transduce it into biochemical signals to trigger vascular adaptive responses. Among the various shear-induced signaling molecules, reactive oxygen species (ROS) and nitric oxide (NO) have been implicated in vascular homeostasis and diseases. In this… CONTINUE READING
    184 Citations
    Low shear stress induces endothelial reactive oxygen species via the AT1R/eNOS/NO pathway
    • 15
    ROS and NO Dynamics in Endothelial Cells Exposed to Exercise-Induced Wall Shear Stress
    • 1
    Oscillatory Shear Stress Induces Oxidative Stress via TLR4 Activation in Endothelial Cells
    • 1
    • Highly Influenced
    • PDF
    Pressure vs Flow-Induced Pulmonary Hypertension
    • PDF
    Effects of shear stress on endothelial cells: go with the flow
    • 138
    Systems biology analysis of longitudinal functional response of endothelial cells to shear stress
    • 33
    • PDF
    Low shear stress damages endothelial function through STAT1 in endothelial cells (ECs)
    • 1

    References

    SHOWING 1-10 OF 135 REFERENCES
    Reactive oxygen species are involved in shear stress-induced intercellular adhesion molecule-1 expression in endothelial cells.
    • 184
    Increase of reactive oxygen species (ROS) in endothelial cells by shear flow and involvement of ROS in shear‐induced c‐fos expression
    • 173
    Shear stress, reactive oxygen species, and arterial structure and function.
    • 41
    Cyclic stretch, reactive oxygen species, and vascular remodeling.
    • K. Birukov
    • Biology, Medicine
    • Antioxidants & redox signaling
    • 2009
    • 157
    Redox signalling in vascular responses to shear and stretch.
    • S. Lehoux
    • Biology, Medicine
    • Cardiovascular research
    • 2006
    • 120
    • PDF
    Molecular mechanisms responsible for the atheroprotective effects of laminar shear stress.
    • S. P'an
    • Chemistry, Medicine
    • Antioxidants & redox signaling
    • 2009
    • 92
    Anti-atherogenic effect of laminar shear stress via Nrf2 activation.
    • 55
    Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases.
    • Y. Boo, Hanjoong Jo
    • Biology, Medicine
    • American journal of physiology. Cell physiology
    • 2003
    • 356
    • PDF