Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications

  title={Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications},
  author={H. Hsieh and Ching-Ann Liu and B. Huang and Anne HH Tseng and D. Wang},
  journal={Journal of Biomedical Science},
  pages={3 - 3}
  • H. Hsieh, Ching-Ann Liu, +2 authors D. Wang
  • Published 2013
  • Medicine, Biology
  • Journal of Biomedical Science
  • Hemodynamic shear stress, the blood flow-generated frictional force acting on the vascular endothelial cells, is essential for endothelial homeostasis under normal physiological conditions. Mechanosensors on endothelial cells detect shear stress and transduce it into biochemical signals to trigger vascular adaptive responses. Among the various shear-induced signaling molecules, reactive oxygen species (ROS) and nitric oxide (NO) have been implicated in vascular homeostasis and diseases. In this… CONTINUE READING
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