Shear fluid-induced Ca2+ release and the role of mitochondria in rat cardiac myocytes.

@article{Belmonte2008ShearFC,
  title={Shear fluid-induced Ca2+ release and the role of mitochondria in rat cardiac myocytes.},
  author={Steve Belmonte and Martin Morad},
  journal={Annals of the New York Academy of Sciences},
  year={2008},
  volume={1123},
  pages={58-63}
}
Cardiac myocyte contraction occurs when Ca2+ influx through voltage-gated L-type Ca2+ channels causes Ca2+ release from ryanodine receptors of the sarcoplasmic reticulum (SR). Although mitochondria occupy about 35% of the cell volume in rat cardiac myocytes, and are thought to be located <300 nm from the junctional SR, their role in the beat-to-beat… CONTINUE READING