Shear flow-induced motility of Dictyostelium discoideum cells on solid substrate.

  title={Shear flow-induced motility of Dictyostelium discoideum cells on solid substrate.},
  author={Emmanuel D{\'e}cav{\'e} and Didier Rieu and J{\'e}r{\'e}mie Dalous and S{\'e}bastien Fache and Yves Br{\'e}chet and Bertrand Fourcade and Michel Satre and Franz Bruckert},
  journal={Journal of cell science},
  volume={116 Pt 21},
Application of a mild hydrodynamic shear stress to Dicytostelium discoideum cells, unable to detach cells passively from the substrate, triggers a cellular response consisting of steady membrane peeling at the rear edge of the cell and periodic cell contact extensions at its front edge. Both processes require an active actin cytoskeleton. The cell movement induced by the hydrodynamic forces is very similar to amoeboid cell motion during chemotaxis, as for its kinematic parameters and for the… CONTINUE READING


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