Shear-enhanced binding of intestinal colonization factor antigen I of enterotoxigenic Escherichia coli.

Abstract

In the intestine, enterotoxigenic Escherichia coli works against peristaltic forces, adhering to the epithelium via the colonization factor antigen I (CFA/I) fimbrial adhesin CfaE. The CfaE adhesin is similar in localization and tertiary (but not primary) structure to FimH, the type 1 fimbrial adhesin of uropathogenic E. coli, which shows shear-dependent… (More)
DOI: 10.1111/j.1365-2958.2010.07116.x

Topics

8 Figures and Tables