Shear effects on aluminum phosphate adjuvant particle properties in vaccine drug products.

Abstract

Adjuvant-containing drug products can be exposed to high levels of interfacial shear during manufacture. This may affect the integrity of the adjuvant, alter its interaction with the drug substance or change the physical characteristics of the drug product. In this study, a solid-liquid interfacial shear device was used to investigate the shear response of… (More)
DOI: 10.1002/jps.24127

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