Corpus ID: 237592787

Shear-driven solidification and nonlinear elasticity in epithelial tissues

  title={Shear-driven solidification and nonlinear elasticity in epithelial tissues},
  author={Junxiang Huang and James O. Cochran and Suzanne M. Fielding and Matteo Marchetti and Dapeng Bi},
Biological processes, from morphogenesis to tumor invasion, spontaneously generate shear stresses inside living tissue. The mechanisms that govern the transmission of mechanical forces in epithelia and the collective response of the tissue to bulk shear deformations remain, however, poorly understood. Using a minimal cellbased computational model, we investigate the constitutive relation of confluent tissues under simple shear deformation. We show that an undeformed fluid-like tissue acquires… Expand

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