Shear distribution and variability in the USP Apparatus 2 under turbulent conditions.

  title={Shear distribution and variability in the USP Apparatus 2 under turbulent conditions.},
  author={Joseph Kukura and Jennifer L. Baxter and Fernando J. Muzzio},
  journal={International journal of pharmaceutics},
  volume={279 1-2},
Computational analysis is used to examine the hydrodynamic environment within the USP Apparatus II at common operating conditions. Experimental validation of the computational model shows that the simulations of fluid motion match the dispersion of dye observed in experiments. The computations are then used to obtain data that cannot be easily measured with experiments, specifically the distribution of shear forces within the media and along the wall. Results show that the shear environment is… CONTINUE READING

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