Shc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis.

@article{Hagopian2012ShcPI,
  title={Shc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis.},
  author={Kevork Hagopian and Alexey Tomilov and Natalia B Tomilova and Kyoungmi Kim and Sandra L. Taylor and Adam Lam and Gino A Cortopassi and Roger B. McDonald and Jon Jay Ramsey},
  journal={Metabolism: clinical and experimental},
  year={2012},
  volume={61 12},
  pages={
          1703-13
        }
}
  • Kevork Hagopian, Alexey Tomilov, +6 authors Jon Jay Ramsey
  • Published in
    Metabolism: clinical and…
    2012
  • Biology, Medicine
  • OBJECTIVES ShcKO mice have low body fat and resist weight gain on a high fat diet, indicating that Shc proteins may influence enzymes involved in β-oxidation. To investigate this idea, the activities of β-oxidation and ketone body metabolism enzymes were measured. METHODS The activities of β-oxidation enzymes (acyl-CoA dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase and ketoacyl-CoA thiolase) in liver and hindlimb skeletal muscle, ketolytic enzymes (acetoacetyl-CoA thiolase, β-hydroxybutyrate… CONTINUE READING

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