Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor-2 and platelet-derived growth factor receptor-beta signaling.

@article{Rolny2005ShbPB,
  title={Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor-2 and platelet-derived growth factor receptor-beta signaling.},
  author={Charlotte Rolny and Lingge Lu and Nina Agren and Ingrid Nilsson and Cheryl Roe and Gene C Webb and Michael Welsh},
  journal={Experimental cell research},
  year={2005},
  volume={308 2},
  pages={381-93}
}
The mechanisms controlling blood vessel formation during early embryonal development have only partly been elucidated. Shb is an adaptor protein previously implicated in the angiogenic response to vascular endothelial growth factor (VEGF). To elucidate a possible role of Shb in embryonic vascular development, wild-type and SH2 domain mutated (R522K) Shb were overexpressed in murine embryonic stem (ES) cells. Embryoid bodies (EBs) differentiating from Shb-overexpressing ES cells in vitro were… CONTINUE READING

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