Sharpening nature's tools for efficient tuberculosis control: A review of the potential role and development of host-directed therapies and strategies for targeted respiratory delivery.

@article{OConnor2016SharpeningNT,
  title={Sharpening nature's tools for efficient tuberculosis control: A review of the potential role and development of host-directed therapies and strategies for targeted respiratory delivery.},
  author={Gemma O'Connor and Laura E. Gleeson and Aidan Fagan-Murphy and Sally-Ann Cryan and Mary P. O'Sullivan and Joseph Keane},
  journal={Advanced drug delivery reviews},
  year={2016},
  volume={102},
  pages={
          33-54
        }
}
Centuries since it was first described, tuberculosis (TB) remains a significant global public health issue. Despite ongoing holistic measures implemented by health authorities and a number of new oral treatments reaching the market, there is still a need for an advanced, efficient TB treatment. An adjunctive, host-directed therapy designed to enhance endogenous pathways and hence compliment current regimens could be the answer. The integration of drug repurposing, including synthetic and… CONTINUE READING

Figures and Topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

All-trans Retinoic Acid Augments Autophagy during Intracellular Bacterial Infection.

  • American journal of respiratory cell and molecular biology
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND

Lipids in infectious diseases - The case of AIDS and tuberculosis.

  • Biochimica et biophysica acta. Biomembranes
  • 2017
VIEW 1 EXCERPT
CITES METHODS

References

Publications referenced by this paper.
SHOWING 1-10 OF 294 REFERENCES

Adjunctive therapy with interferon-gamma for the treatment of pulmonary tuberculosis: a systematic review.

  • International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
  • 2011
VIEW 15 EXCERPTS
HIGHLY INFLUENTIAL

Inhaled drug treatment for tuberculosis: Past progress and future prospects.

  • Journal of controlled release : official journal of the Controlled Release Society
  • 2016
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Active tuberculosis during temsirolimus and bevacizumab treatment.

  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2013
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Reactivation of tuberculosis during temsirolimus therapy

  • Investigational New Drugs
  • 2010
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Thalidomide and tuberculosis.

VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL