Sharpened Cochlear Tuning in a Mouse with a Genetically Modified Tectorial Membrane

  title={Sharpened Cochlear Tuning in a Mouse with a Genetically Modified Tectorial Membrane},
  author={Ian John Russell and P. Kevin Legan and Victoria A. Lukashkina and Andrei N Lukashkin and Richard J Goodyear and Guy. P Richardson},
  booktitle={Nature Neuroscience},
Frequency tuning in the cochlea is determined by the passive mechanical properties of the basilar membrane and active feedback from the outer hair cells, sensory-effector cells that detect and amplify sound-induced basilar membrane motions. The sensory hair bundles of the outer hair cells are imbedded in the tectorial membrane, a sheet of extracellular matrix that overlies the cochlea's sensory epithelium. The tectorial membrane contains radially organized collagen fibrils that are imbedded in… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 47 references

Nanomechanics of the subtectorial space caused by electromechanics of cochlear outer hair cells.

Proceedings of the National Academy of Sciences of the United States of America • 2006

The tectorial membrane resonance: manifestations in the cochlear acoustical and neural responses

AN Lukashkin, JK Smith, IJ. Russell
J. Acoust. Soc. Am • 2006

A deafness mutation demonstrates a second role for the tectorial membrane in hearing

PK Legan
Nat. Neurosci • 2005

Force on inner hair cell cilia

CR Steele, S. Puria
Int. J. Solids. Struct • 2005

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