Sharing of MHC haplotypes among patients with systemic lupus erythematosus from unrelated Caucasian multicase families: disease association with the extended haplotype [HLA-B8, SC01, DR17].

@article{Truedsson1995SharingOM,
  title={Sharing of MHC haplotypes among patients with systemic lupus erythematosus from unrelated Caucasian multicase families: disease association with the extended haplotype [HLA-B8, SC01, DR17].},
  author={Lennart Truedsson and Gunnar K. Sturfelt and P{\aa}l Johansen and Ola Nived and Britt Thuresson},
  journal={The Journal of rheumatology},
  year={1995},
  volume={22 10},
  pages={1852-61}
}
OBJECTIVE Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease often clustered in families. We investigated the association between MHC haplotypes and SLE in multicase Caucasian families. METHODS Ten consecutive families with 2 or more patients with SLE, in total 27 patients among 66 individuals, were studied. MHC haplotypes were determined by typing for HLA-A, B, C, DR, and DQ by serological and DNA methods. Complotypes were determined by protein typing and C4 gene… CONTINUE READING

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