Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

@article{Gandal2018SharedMN,
  title={Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap},
  author={Michael J. Gandal and Jillian R Haney and Neelroop N Parikshak and Virpi Leppa and Gokul Ramaswami and Chris L Hartl and Andrew J. Schork and Vivek Appadurai and Alfonso Buil and Thomas M Werge and Chunyu Liu and Kevin P. White and Steve Horvath and Daniel H. Geschwind},
  journal={Science},
  year={2018},
  volume={359},
  pages={693-697}
}
The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders—autism, schizophrenia, bipolar disorder, depression, and alcoholism—compared with matched controls. We identified patterns of shared and distinct gene… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 67 references

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

Y Zhang
Neuron • 2016

peer-reviewed) is the author/funder. All rights reserved No reuse allowed without permission. The copyright holder for this preprint (which was not

peer-reviewed) is the author/funder. All rights reserved No reuse allowed without permission. The copyright holder for this preprint (which was not • 2016

Meta-analysis of the heritability of human traits based on fifty years of twin studies

T J. C Polderman
Nat Genet • 2015

Network and Pathway Analysis Subgroup of Psychiatric Genomics Consortium, Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

Nature Neuroscience • 2015

Similar Papers

Loading similar papers…