Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine viruses.

@article{Belyakov2003SharedMO,
  title={Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine viruses.},
  author={Igor M. Belyakov and Patricia L. Earl and Amiran H. Dzutsev and Vladimir A. Kuznetsov and Michael Lemon and Linda S. Wyatt and James Thomas Snyder and Jeffrey D. Ahlers and Genoveffa Franchini and Bernard Moss and Jay A. Berzofsky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 16},
  pages={
          9458-63
        }
}
The concern about bioterrorism with smallpox has raised the possibility of widespread vaccination, but the greater prevalence of immunocompromised individuals today requires a safer vaccine, and the mechanisms of protection are not well understood. Here we show that, at sufficient doses, the protection provided by both modified vaccinia Ankara and NYVAC replication-deficient vaccinia viruses, safe in immunocompromised animals, was equivalent to that of the licensed Wyeth vaccine strain against… CONTINUE READING

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