Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder

  title={Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder},
  author={Nanda N. J. Rommelse and Barbara Franke and Hilde M. Geurts and Catharina A. Hartman and Jan K. Buitelaar},
  journal={European Child \& Adolescent Psychiatry},
  pages={281 - 295}
Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are both highly heritable neurodevelopmental disorders. Evidence indicates both disorders co-occur with a high frequency, in 20–50% of children with ADHD meeting criteria for ASD and in 30-80% of ASD children meeting criteria for ADHD. This review will provide an overview on all available studies [family based, twin, candidate gene, linkage, and genome wide association (GWA) studies] shedding light on the role of… 

Examining the clinical and genetic overlap of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder traits

Attention deficit hyperactivity disorder (ADHD) is a common and impairing neurodevelopmental disorder, which frequently co-occurs with autism spectrum disorder (ASD). Both disorders are highly

Biological Overlap of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder: Evidence From Copy Number Variants

Genetic Overlap Between Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in SHANK2 Gene

SHANK2 could be considered a potential pleiotropic gene underlying the genetic overlap between ADHD and ASD, which might contribute partly to their high comorbidity in the afflicted children.

Common Genetic Risk Factors in ASD and ADHD Co-occurring Families

Candidate genes and pathways identified in this study provide a better understanding of the genetic etiology of ASD and ADHD and will lead to new diagnostic or therapeutic interventions for Autism and ADHD in the future.

Shared familial transmission of autism spectrum and attention-deficit/hyperactivity disorders.

Assessment of the prevalence, rates of comorbidity, and familial transmission of both autism spectrum disorders and attention-deficit/hyperactivity disorder in a large population-based sample of children during a recent 7 year period found ADHD and ASD have a partially overlapping diathesis.

Genetic Overlap Among Autism Spectrum Disorders and Other Neuropsychiatric Disorders

The findings from these studies converge on postsynaptic proteins, such as L-type calcium channels and proteins involved in N-methyl-D-aspartate signaling and indicate that synaptic mechanisms may underlie many different neuropsychiatric disorders, including ASD.

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

A genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls identifies variants surpassing genome- wide significance in 12 independent loci and implicates neurodevelopmental pathways and conserved regions of the genome as being involved in underlying ADHD biology.

Genetics in the ADHD Clinic: How Can Genetic Testing Support the Current Clinical Practice?

A brief review of the genome-wide and candidate gene association studies with a focus on the clinical aspects, summarizing findings of ADHD disease risk, ADHD core symptoms as dimensional traits, and other traits frequently associated with ADHD which may contribute to the susceptibility to other comorbid psychiatric disorders.

Identification of biobehavioral markers of neurodevelopmental disorders in twins

The results support that systemic preand postnatal elemental dysregulation increase ASD risk, and an association between early medical events and ASD risk is found, and point to a cumulative multifactor threshold model, including both genetic and NSE components in the etiology of ASD.



Genome-wide association studies in ADHD

The GWAS performed so far in ADHD, though far from conclusive, provide a first glimpse at genes for the disorder, and findings from the individual studies converge to paint an interesting picture.

Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism.

Using affected-sib-pair analysis in 203 families to localize the first major susceptibility locus for ADHD to a 12-cM region on chromosome 16p13, this work suggests that variations in a gene on 16 p13 may contribute to common deficits found in both ADHD and autism.

Genome‐wide association scan of attention deficit hyperactivity disorder

  • B. NealeJ. Lasky-Su S. Faraone
  • Biology, Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
None of the SNP association tests achieved genome‐wide significance, indicating that larger samples may be required to identify risk loci for ADHD, and a systemic bias in family‐based association is identified.

Association of ADHD, tics, and anxiety with dopamine transporter (DAT1) genotype in autism spectrum disorder.

Results suggest that the extraordinary variability in ASD clinical phenotypes may be explained in part by the same genes that are implicated in a host of other psychiatric disorders in non-ASD populations.

A Common Variant in DRD3 Receptor Is Associated with Autism Spectrum Disorder

Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders

Autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders and shared with familiality of ADHD in males.

ADHD: strategies to unravel its genetic architecture.

  • J. Buitelaar
  • Psychology, Biology
    Journal of neural transmission. Supplementum
  • 2005
Eight factors that complicate research into genetically complex disorders as ADHD are described, which include that multiple genes of small main effects are involved rather than main genes, the relevant phenotype is unknown, and presence of clinical heterogeneity.

The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes

Examining single-nucleotide polymorphisms spanning 51 candidate genes involved in the regulation of neurotransmitter pathways, particularly dopamine, norepinephrine and serotonin pathways, found nominal significance with one or more SNPs in 18 genes, including the two most replicated findings in the literature: DRD4 and DAT1.

Autism, ADHD, mental retardation and behavior problems in 100 individuals with 22q11 deletion syndrome.

What’s new in autism?

This review on autism spectrum disorder (ASD) focusses on recent insights in the clinical picture, such as continuity of the phenotype and the concept of broader phenotype, on epidemiology and on