Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder

@article{Rommelse2010SharedHO,
  title={Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder},
  author={Nanda N. J. Rommelse and Barbara Franke and Hilde M. Geurts and Catharina A. Hartman and Jan K. Buitelaar},
  journal={European Child \& Adolescent Psychiatry},
  year={2010},
  volume={19},
  pages={281 - 295}
}
Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are both highly heritable neurodevelopmental disorders. Evidence indicates both disorders co-occur with a high frequency, in 20–50% of children with ADHD meeting criteria for ASD and in 30-80% of ASD children meeting criteria for ADHD. This review will provide an overview on all available studies [family based, twin, candidate gene, linkage, and genome wide association (GWA) studies] shedding light on the role of… 

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References

SHOWING 1-10 OF 106 REFERENCES

Genome-wide association studies in ADHD

The GWAS performed so far in ADHD, though far from conclusive, provide a first glimpse at genes for the disorder, and findings from the individual studies converge to paint an interesting picture.

Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism.

Using affected-sib-pair analysis in 203 families to localize the first major susceptibility locus for ADHD to a 12-cM region on chromosome 16p13, this work suggests that variations in a gene on 16 p13 may contribute to common deficits found in both ADHD and autism.

Genome‐wide association scan of attention deficit hyperactivity disorder

  • B. NealeJ. Lasky-Su S. Faraone
  • Biology, Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
None of the SNP association tests achieved genome‐wide significance, indicating that larger samples may be required to identify risk loci for ADHD, and a systemic bias in family‐based association is identified.

Association of ADHD, tics, and anxiety with dopamine transporter (DAT1) genotype in autism spectrum disorder.

Results suggest that the extraordinary variability in ASD clinical phenotypes may be explained in part by the same genes that are implicated in a host of other psychiatric disorders in non-ASD populations.

A Common Variant in DRD3 Receptor Is Associated with Autism Spectrum Disorder

Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders

Autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders and shared with familiality of ADHD in males.

ADHD: strategies to unravel its genetic architecture.

  • J. Buitelaar
  • Psychology, Biology
    Journal of neural transmission. Supplementum
  • 2005
Eight factors that complicate research into genetically complex disorders as ADHD are described, which include that multiple genes of small main effects are involved rather than main genes, the relevant phenotype is unknown, and presence of clinical heterogeneity.

The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes

Examining single-nucleotide polymorphisms spanning 51 candidate genes involved in the regulation of neurotransmitter pathways, particularly dopamine, norepinephrine and serotonin pathways, found nominal significance with one or more SNPs in 18 genes, including the two most replicated findings in the literature: DRD4 and DAT1.

Autism, ADHD, mental retardation and behavior problems in 100 individuals with 22q11 deletion syndrome.

What’s new in autism?

This review on autism spectrum disorder (ASD) focusses on recent insights in the clinical picture, such as continuity of the phenotype and the concept of broader phenotype, on epidemiology and on
...