Shared genomic segment analysis. Mapping disease predisposition genes in extended pedigrees using SNP genotype assays.

@article{Thomas2008SharedGS,
  title={Shared genomic segment analysis. Mapping disease predisposition genes in extended pedigrees using SNP genotype assays.},
  author={Alun Thomas and Nicola J. Camp and James Michael Farnham and Kristina Allen-Brady and Lisa A. Cannon-Albright},
  journal={Annals of human genetics},
  year={2008},
  volume={72 Pt 2},
  pages={279-87}
}
We examine the utility of high density genotype assays for predisposition gene localization using extended pedigrees. Results for the distribution of the number and length of genomic segments shared identical by descent among relatives previously derived in the context of genomic mismatch scanning are reviewed in the context of dense single nucleotide polymorphism maps. We use long runs of loci at which cases share a common allele identically by state to localize hypothesized predisposition… CONTINUE READING

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