Shared genetic control of expression and methylation in peripheral blood

@article{Shakhbazov2016SharedGC,
  title={Shared genetic control of expression and methylation in peripheral blood},
  author={Konstantin Shakhbazov and Joseph E. Powell and Gibran Hemani and Anjali K. Henders and Nicholas G. Martin and Peter M. Visscher and Grant W. Montgomery and Allan F. McRae},
  journal={BMC Genomics},
  year={2016},
  volume={17},
  pages={1-13}
}
Expression QTLs and epigenetic marks are often employed to provide an insight into the possible biological mechanisms behind GWAS hits. A substantial proportion of the variation in gene expression and DNA methylation is known to be under genetic control. We address the proportion of genetic control that is shared between these two genomic features. An exhaustive search for pairwise phenotypic correlations between gene expression and DNA methylation in samples from human blood (n = 610) was… CONTINUE READING