Shared antigenic epitopes and pathobiological functions of anti-p185(her2/neu) monoclonal antibodies.

@article{Zhang1999SharedAE,
  title={Shared antigenic epitopes and pathobiological functions of anti-p185(her2/neu) monoclonal antibodies.},
  author={Hongtao Zhang and Qiang Wang and Kathleen Theresa Montone and Jennifer E. Peavey and Jeffrey Adam Drebin and Ramachandran Murali},
  journal={Experimental and molecular pathology},
  year={1999},
  volume={67 1},
  pages={
          15-25
        }
}
We have studied two anti-p185 antibodies: the monoclonal antibody 7. 16.4 and rhuMAb 4D5, which were raised against the the ectodomain of rat (p185(neu)), and the human (p185(her2/neu)) homolog, respectively. Studies on the structure of these two antibodies indicate that they share structural similarity in the variable region, especially the CDR3 region, which determines the antibody-antigen interaction. Further studies by flow cytometry revealed that 7.16.4 can compete with rhuMAb4D5 for… CONTINUE READING
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