Shared and Distinct Functions of the Transcription Factors IRF4 and IRF8 in Myeloid Cell Development

@article{Yamamoto2011SharedAD,
  title={Shared and Distinct Functions of the Transcription Factors IRF4 and IRF8 in Myeloid Cell Development},
  author={Michio Yamamoto and Takayuki Kato and C. Hotta and A. Nishiyama and D. Kurotaki and M. Yoshinari and M. Takami and M. Ichino and M. Nakazawa and T. Matsuyama and R. Kamijo and S. Kitagawa and K. Ozato and T. Tamura},
  journal={PLoS ONE},
  year={2011},
  volume={6}
}
Interferon regulatory factor (IRF) 8 and IRF4 are structurally-related, hematopoietic cell-specific transcription factors that cooperatively regulate the differentiation of dendritic cells and B cells. Whilst in myeloid cells IRF8 is known to modulate growth and differentiation, the role of IRF4 is poorly understood. In this study, we show that IRF4 has activities similar to IRF8 in regulating myeloid cell development. The ectopic expression of IRF4 in myeloid progenitor cells in vitro inhibits… Expand
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  • Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
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TLDR
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