Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma.

@article{Kraus1995SharedAL,
  title={Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma.},
  author={J A Kraus and Jens Koopmann and Peter Kaskel and David Maintz and Sebastian Brandner and Johannes Schramm and David N Louis and Otmar Dieter Wiestler and Andreas von Deimling},
  journal={Journal of neuropathology and experimental neurology},
  year={1995},
  volume={54 1},
  pages={91-5}
}
Loss of heterozygosity (LOH) in specific chromosomal regions, which are likely to harbor tumor suppressor genes, has been associated with human gliomas. In this study we have analyzed astrocytic and oligodendroglial tumors for LOH on chromosomes 1 and 19. By microsatellite analysis LOH was found on chromosome arm 1p in 6/15 oligodendrogliomas WHO grade II and III, 12/25 oligoastrocytomas WHO grade II and III, 6/79 glioblastomas WHO grade IV, 5/44 astrocytomas WHO grade II and III and 0/23… CONTINUE READING

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