Shared RNA-binding sites for interacting members of the Drosophila ELAV family of neuronal proteins

@article{Borgeson2005SharedRS,
  title={Shared RNA-binding sites for interacting members of the Drosophila ELAV family of neuronal proteins},
  author={Claudia D. Borgeson and Marie-Laure Samson},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={6372 - 6383}
}
The product of the Drosophila embryonic lethal abnormal visual system is a conserved protein (ELAV) necessary for normal neuronal differentiation and maintenance. It possesses three RNA-binding domains and is involved in the regulation of RNA metabolism. The long elav 3'-untranslated region (3'-UTR) is necessary for autoregulation. We used RNA-binding assays and in vitro selection to identify the ELAV best binding site in the elav 3'-UTR. This site resembles ELAV-binding sites identified… CONTINUE READING

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