Shared Gene Expression Alterations in Nasal and Bronchial Epithelium for Lung Cancer Detection

@inproceedings{PerezRogers2017SharedGE,
  title={Shared Gene Expression Alterations in Nasal and Bronchial Epithelium for Lung Cancer Detection},
  author={Joseph F. Perez-Rogers and Joseph Gerrein and Christina Anderlind and Gang Liu and Sherry Zhang and Yuriy O. Alekseyev and Kate Porta Smith and Duncan Whitney and William E. Johnson and David A. Elashoff and Steven Dubinett and Jerome S. Brody and Avrum Spira and Marc E. Lenburg},
  year={2017}
}
Background: We previously derived and validated a bronchial epithelial gene expression biomarker to detect lung cancer in current and former smokers. Given that bronchial and nasal epithelial gene expression are similarly altered by cigarette smoke exposure, we sought to determine if cancer-associated gene expression might also be detectable in the more readily accessible nasal epithelium. Methods: Nasal epithelial brushings were prospectively collected from current and former smokers… CONTINUE READING
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