Shaping up the protein folding funnel by local interaction: lesson from a structure prediction study.

@article{Chikenji2006ShapingUT,
  title={Shaping up the protein folding funnel by local interaction: lesson from a structure prediction study.},
  author={George Chikenji and Yoshimi Fujitsuka and Shoji Takada},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 9},
  pages={
          3141-6
        }
}
Predicting protein tertiary structure by folding-like simulations is one of the most stringent tests of how much we understand the principle of protein folding. Currently, the most successful method for folding-based structure prediction is the fragment assembly (FA) method. Here, we address why the FA method is so successful and its lesson for the folding problem. To do so, using the FA method, we designed a structure prediction test of "chimera proteins." In the chimera proteins, local… CONTINUE READING
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