Shaping phenotype, function, and survival of dendritic cells by cytomegalovirus-encoded IL-10.

@article{Raftery2004ShapingPF,
  title={Shaping phenotype, function, and survival of dendritic cells by cytomegalovirus-encoded IL-10.},
  author={Martin J. Raftery and D C Florian Wieland and Stefanie Gronewald and Annette Alexandra Kraus and Thomas Giese and G{\"u}nther Sch{\"o}nrich},
  journal={Journal of immunology},
  year={2004},
  volume={173 5},
  pages={3383-91}
}
Human dendritic cells (DCs) are essential for the antiviral immune response and represent a strategically important target for immune evasion of viruses, including human CMV (HCMV). Recently, HCMV has been discovered to encode a unique IL-10 homologue (cmvIL-10). In this study we investigated the capacity of cmvIL-10 to shape phenotype, function, and survival of DCs. For comparison we included human IL-10 and another IL-10 homologue encoded by EBV, which does not directly target DCs… CONTINUE READING