Shaping and reshaping CD8+ T-cell memory

  title={Shaping and reshaping CD8+ T-cell memory},
  author={John T Harty and Vladimir P Badovinac},
  journal={Nature Reviews Immunology},
The ability to develop and sustain populations of memory T cells after infection or immunization is a hallmark of the adaptive immune response and a basis for protective vaccination against infectious disease. Technical advances that allow direct ex vivo identification and characterization of antigen-specific CD8+ T cells at various stages of the response to infection or vaccination in mouse models have fuelled efforts to characterize the factors that control memory CD8+ T-cell generation. Here… CONTINUE READING
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