Shape-specific recognition in the structure of the Vts1p SAM domain with RNA

  title={Shape-specific recognition in the structure of the Vts1p SAM domain with RNA},
  author={Florian C. Oberstrass and Albert Lee and Richard Stefl and Michael J. Janis and Guillaume F Chanfreau and Fr{\'e}d{\'e}ric Hai-Trieu Allain},
  journal={Nature Structural &Molecular Biology},
Although the abundant sterile alpha motif (SAM) domain was originally classified as a protein-protein interaction domain, it has recently been shown that certain SAM domains have the ability to bind RNA, defining a new type of post-transcriptional gene regulator. To further understand the function of SAM-RNA recognition, we determined the solution structures of the SAM domain of the Saccharomyces cerevisiae Vts1p (Vts1p-SAM) and the Smaug response element (SRE) stem-loop RNA as a complex and in… CONTINUE READING
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