Shape of Nanoparticles as a Design Parameter to Improve Docetaxel Antitumor Efficacy.

@article{Guo2018ShapeON,
  title={Shape of Nanoparticles as a Design Parameter to Improve Docetaxel Antitumor Efficacy.},
  author={Yifei Guo and Shuang Yi Zhao and Hanhong Qiu and Ting Wang and Yanna Zhao and Xiangtao Wang and Zhengqi Dong},
  journal={Bioconjugate chemistry},
  year={2018},
  volume={29 4},
  pages={
          1302-1311
        }
}
It was reported that the shape of nanocarriers played an important role in achieving a better therapeutic effect. To optimize the morphology and enhance the antitumor efficacy, in this study based on the amphiphilic PAMAM- b-OEG codendrimer (POD), docetaxel-loaded spherical and flake-like nanoparticles (DTX nanospheres and nanosheets) were prepared via an antisolvent precipitation method with similar particle size, surface charge, stability, and release profiles. The feed weight ratio of DTX… CONTINUE READING
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