Shape-mediated biological effects of mesoporous silica nanoparticles.

@article{Hao2014ShapemediatedBE,
  title={Shape-mediated biological effects of mesoporous silica nanoparticles.},
  author={Nanjing Hao and Laifeng Li and Fangqiong Tang},
  journal={Journal of biomedical nanotechnology},
  year={2014},
  volume={10 10},
  pages={
          2508-38
        }
}
For biomedical applications, mesoporous silica nanoparticles (MSNs)-based theranostic agents have shown to be a promising alternative. Rational design of particulate systems should consider, beside the physicochemical properties of particle size and surface chemistry, shape features as aspect ratio (AR) and morphology. Recent advances of fabrication technologies for manufacturing different shaped MSNs and evaluation means of its in vitro and in vivo biological performance provide new aspects… 
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36 Citations
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Methods Citations
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36 Citations

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The pharmacokinetic results demonstrated that nifedipine(NI)-loaded NLR had a higher bioavailability than NI-loaded NSR and NS and the in vivo biodistribution showed that all the orally administered MSNs were mainly taken up by the liver, and kidney.
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