Shape-induced asymmetric diffusion in dendritic spines allows efficient synaptic AMPA receptor trapping.

@article{Kusters2013ShapeinducedAD,
  title={Shape-induced asymmetric diffusion in dendritic spines allows efficient synaptic AMPA receptor trapping.},
  author={Remy Kusters and Lukas C Kapitein and Casper C Hoogenraad and Cornelis Storm},
  journal={Biophysical journal},
  year={2013},
  volume={105 12},
  pages={2743-50}
}
Dendritic spines are the primary postsynaptic sites of excitatory neurotransmission in the brain. They exhibit a remarkable morphological variety, ranging from thin protrusions, to stubby shapes, to bulbous mushroom shapes. The remodeling of spines is thought to regulate the strength of the synaptic connection, which depends vitally on the number and the spatial distribution of AMPA-type glutamate receptors (AMPARs). We present numerical and analytical analyses demonstrating that this shape… CONTINUE READING
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